6:00-8:00pm

Informal family get-together

Hosted by Bob and Lorna Day (The Sam Day Foundation)

8:30am

Charles Keller (cc-TDI)

Welcome and Introductions

Lab Tour

9:00am

Charles Keller (cc-TDI)

Overview from an Academic and Pharma Perspective (childhood cancer treatment, clinical trials, basic science research, how to cure cancer from a grassroots perspective “The Josh Sommer Paradigm”, vocabulary)

9:45am

Andy Woods (cc-TDI)

Project Introduction and Team Organization

10:00am

Jeff Toretsky (Georgetown)

EWSR1 Cancers Overview (clinical summary, biology, therapeutics)

11:00am

Agnieszka Wozniak (KU Leuven)

Clear Cell Sarcoma Clinical Trials (crizotinib and beyond)

12:35pm

LUNCH  (provided)

1:35pm

Charles Keller (cc-TDI)

Concise summaries of cc-TDI clear cell sarcoma and epithelioid sarcoma research programs

2:00pm

Paul Huang (ICR London)

Sarcoma Proteomics (EWSR1 family cancers and CCS)

3:00pm

Ken Crawford (cc-TDI)

Robotic Drug Screen:

Stage 1 of 2

4:00pm

Reception with Lorna, Nathan and Renee

6:00pm

Group dinners with speakers (locations TBA)

8:00am

Kevin Jones (University of Utah)

CCS Mouse Models

9:00am

Tyuji Hoshino (Chiba University)

Drug Design (super-powered by the IBM WORLD COMMUNITY GRID) 

11:00am

Xiangshu Xiao (OHSU)

666-15 for CCS

12:00pm

 

LUNCH with SCIENCE: Research at cc-TDI

1:00pm

Charles Keller (cc-TDI)

Artisan Biopharma – Families Developing and “Taking Stock” in EWSR1 Drugs (the Pillsbury Bakeoff of EWSR1 therapies, akin to ALS-TDI (aka, “Ice Bucket Challenge”)

2:00pm

Gwenn Hanson and Steve Basham (Nurix Pharmaceuticals)

Proteosome-enabled Therapeutics: The New Frontier

3:00pm

Charles Keller (cc-TDI)

Project Work Time and Working Group Discussions

4:00pm

Charles Keller (cc-TDI)

Personalized Therapy – Scientific Considerations

5:00pm

Conclusion to Daily Sessions

8:00am

Project Work Time

9:00am

Michael Cohen (OHSU)

Allosteric modulation of PARP-DNA binding with small molecule inhibitors: a potential therapeutic strategy for treating Ewing Sarcoma 

10:00am

Ganapati Srinivasa (OmicsAutomation)

Genomic Decisions – All in a Day

11:00am

Viktors Berstis (IBM Systems and Technology Group; WorldCommunityGrid.org)

PLENARY LECTURE: The IBM Community Grid Smash Childhood Cancer Program

12:00pm

LUNCH (Provided)

1:00pm

Calleigh Germer (cc-TDI)

Introduction to the cc-TDI Junior Board

1:15pm

Lorna Day (Sam Day Foundation)

Wall of Hope 

Wouldn’t it be Cool if……..

2:00pm

Project Work Time

3:00pm

Joel Michalek (UTHSCSA)

Bayesian Analysis of Xenograft Studies

4:00pm

 

Project Work Time

5:00pm

Conclusion to Daily Sessions

8:00am

Tommy Pham (Nike)

Partnering with Industry

9:00am

Andy Woods (cc-TDI)

How I Became a Full Time Scientist for my Daughter’s Cancer

10:00am

Samuel Rasmussen (cc-TDI)

Egg-static about Preclinical Research

11:00am

Dylan Marchione (University of Pennsylvania)

Lunch and Learn: Proteins from Ancient Tumor Samples – Back to the Future

12:00pm

Ken Crawford (cc-TDI)

Robotic Drug Screen: Stage 2 of 2

1:00pm

Tommy Pham (Nike)

Nike Tour and Off-Site Project Work Time

5:00pm

Conclusion to Daily Sessions

8:00am

Project Work Time

9:00am

Project Finalization

12:00pm

LUNCH (Provided)

1:30pm

Presentation of Completed Group Projects

3:30pm

 

Feedback Session

5:00pm

Nanocourse Conclusion